

Consenting participants complete a baseline assessment and follow-up waves at 9, 18, and 27 months post-baseline.

A systematic probability sample of participants aged 25 to 65 is recruited from residents of the Bronx, NY.

This study utilizes a prospective longitudinal measurement-burst design. Over time, stress-related physiological dysregulation will result in accelerated cognitive decline. Over the long-term, we expect that the effects of chronic stress, from repeated exposure to stressors and regular engagement in URT, will be apparent in dysregulated hypothalamic-pituitary-adrenal (HPA) axis function and inflammation. Over the short-term, we hypothesize that engaging in URT will deplete attentional resources and result in worse cognitive performance in daily life. A key objective of the ESCAPE (Effects of Stress on Cognitive Aging, Physiology, and Emotion) project is to evaluate whether engaging in stress-related unconstructive repetitive thought (URT) is a pathway through which stressful experiences negatively affect cognitive health over the short- and long-term. Despite evidence that psychological stress is an important risk factor for age-related cognitive loss, little research has directly evaluated psychological and physiological mediators of the relationship between stressful experiences and cognitive function.
